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KMID : 0616120110420040379
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Korean Journal of Pharmacognosy
2011 Volume.42 No. 4 p.379 ~ p.385
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Screening of the Inhibitory Activity of Korea Local Plant Extracts against Indoleamine 2,3-dioxygenase (IDO)
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Jang Jun-Pil
Jang Jae-Hyuk
Bae Eun-Young
Jeong Sook-Jung
Kim Hye-Min
Kim Mee-Ree
Soung Nak-Kyun
Kim Bo-Yeon
Ahn Jong-Seog
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Abstract
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Indoleamine 2,3-dioxygenase (IDO) is predicted to be therapeutic target for treatment of cancer and immune disease. Thus, we examined methanol extracts prepared from 156 Korean local plants for their inhibitory effects on IDO in vitro. Among them sixteen extracts showed more than 50% inhibition of IDO activity at the concentration of 30 μg/ml. Especially, the extracts of Platycarya strobilacea, Quercus acutissima, Acer ginnala and Alnus japonica were most potent because their IC50 value were 6.5, 8.1, 3.9 and 4.2 μg/ml, respectively.
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KEYWORD
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Indoleamine 2, 3-dioxygenase, cancer, tryptophan, plant extracts
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